Total synthesis of (-)-spirangien A and its methyl ester.
نویسندگان
چکیده
The first total synthesis of (-)-spirangien A, a cytotoxic and antifungal polyketide of myxobacterial origin, is reported; this exploits a Stork-Wittig olefination and double Stille cross-coupling sequence to install the sensitive pentaene side chain onto a fully elaborated spiroacetal core, leading initially to the methyl ester of spirangien A.
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عنوان ژورنال:
- Chemical communications
دوره 47 شماره
صفحات -
تاریخ انتشار 2008